Looks like a really great tool you are creating.
At my studio we are currently animating 2D games in 3ds Max and Maya, but we are always looking for cheaper and more efficient ways to do our animations. Spine looks ektremely promising.
At GDC in San Francisco this year I watched the "Rayman Reinvented" talk by Ubisoft Montpellier. They showed us how their animation tool GenAnim works.
GenAnim isn't as good looking as spine, but is has an extremely useful feature in setup, where you can put multiple bones on a single "sprite". Then they have a cool simple way to cut-up the sprites mesh so it has poly edges right where you want them.
We are already doing this in Max/Maya by skinning the sprites. But it's difficult and time consuming, so if this was possible in Spine we would diffidently start using this in stead.
Check out the video recording of the Talk on GDC Vault. They show the mentioned feature in a short film starting at 28 min.