@thesnake91 Very sorry to hear you're having issues, and thanks for reporting! Unfortunately this did not occur on our end so far. Did you see any warnings or errors logged in the Console window (e.g. do you see an error message "Internal threading logic error: exited Update loop after timeout!" or anything of this kind)?
We would be very happy if you could send us a minimal Unity reproduction project which still shows this issue. You can send it to contact@esotericsoftware.com, briefly mentioning this forum thread URL so that we know the context. If a minimal project can't be destilled down, we would also be happy to receive a larger project if you can share one.
If that's not possible: To help diagnose the problem in the meantime: does the issue occur only when under Edit - Preferences - Spine section Threading Defaults you have Threaded Mesh Generation or Threaded Animation enabled, does disabling either of the two or disabling both settings fix the situation (assuming you have not set these parameters explicitly on each component like SkeletonRenderer and SkeletonAnimation instead of using Use Global Setting)?
Also if that's possible, could you perhaps attach the debugger to the Unity project and hit Pause in the debugger as soon as it freezes for a longer period of time? Than in the Threads window in the debugging view select the main thread. This should allow us to see where exactly it's stuck.
