Thanks for your answer.
So, it's not others softwares, we checked it. The problem i have is when i do animation with a lot of objects (Bones/images, etc), if i try to hide them for example, the soft freeze and when i check the perfs it use only one core at 100%, and we have to kill the Spine app cauz even if we wait 5 minutes nothing happen.
When i say a lot of objects is like 200 small ones (arround 16x16 pixels). But, that's also happen when i try to hide or move like 30 of them.
I think maybe i reached the limit of the software because, in this file i tests different stuff for work, so i duplicate skeletons when i want to try something else, and even if i don't use those skeletons, i wonder if the fact that they are in the file is enough to make the software laggy ?
Even if it's only 8-10 skeleton, maybe that a reason ?